Why trust our reviews?
We evaluate the quality, quantity, and safety of the scientific evidence for each ingredient so you can make informed decisions for your pet.
Anxiety & Calming Supplement Ingredient Reviews
Select an ingredient to read the full evidence review and recommendations.
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alpha-casozepine
There is weak evidence to support alpha-casozepine as a potential stress-reliever in dogs, though studies were of low quality with a moderate risk of bias
Anxiety & CalmingEvidence Grade Evidence grade C, Limited Evidence -
CBD/cannabidiol
CBD supplementation to dogs may result in a mild decrease in signs associated with stress or anxiety, particularly for anticipated stressful events.
Anxiety & CalmingEvidence Grade Evidence grade C, Limited Evidence -
Melatonin
Melatonin may result in a reduction of stress or anxiety-related behaviors, though it was primarily evaluated as a part of a multimodal approach in many studies, and in anticipation of isolated stressful events.
Anxiety & CalmingEvidence Grade Evidence grade C, Limited Evidence -
Probiotics (behavior)
There is limited overall evidence. Consistent improvements in stress or anxiety in dogs with probiotic supplementation is poorly demonstrated, though research is in the early stages.
Anxiety & CalmingEvidence Grade Evidence grade C, Limited Evidence -
L-theanine
There is weak evidence that L-theanine may aid in the relief of anxiety-related behavior in dogs, though the evidence is of poor quality
Anxiety & CalmingEvidence Grade Evidence grade D, Weak Evidence -
L-tryptophan
L-tryptophan was not demonstrated to reduce markers of stress or anxiety in adult dogs, though the quantity of evidence was low.
Anxiety & CalmingEvidence Grade Evidence grade D, Weak Evidence -
Melissa officinalis (Lemon balm)
There is insufficient evidence to determine evidence-based conclusions regarding the efficacy of melissa officinalis
Anxiety & CalmingEvidence Grade Evidence grade D, Weak Evidence -
Valerian Root
There is insufficient evidence to demonstrate valerian root as an effective calming or anxiety relieving supplement, though early evidence for use as a diffuser did not support efficacy.
Anxiety & CalmingEvidence Grade Evidence grade D, Weak Evidence
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