Anxiety & Behavior Summary - PetEvidenceProject

A quick overview of all 8 reviewed supplements in anxiety & behavior, sorted by evidence grade.

Substance	Grade	TL;DR
CBD/cannabidiol	C	CBD supplementation to dogs may result in a mild decrease in signs associated with stress or anxiety, particularly for anticipated stressful events.	View
Melatonin	C	Melatonin may result in a reduction of stress or anxiety-related behaviors, though it was primarily evaluated as a part of a multimodal approach in many studies, and in anticipation of isolated stressful events.	View
Probiotics (behavior)	C	There is limited overall evidence. Consistent improvements in stress or anxiety in dogs with probiotic supplementation is poorly demonstrated, though research is in the early stages.	View
alpha-casozepine	C	There is weak evidence to support alpha-casozepine as a potential stress-reliever in dogs, though studies were of low quality with a moderate risk of bias	View
L-theanine	D	There is weak evidence that L-theanine may aid in the relief of anxiety-related behavior in dogs, though the evidence is of poor quality	View
L-tryptophan	D	L-tryptophan was not demonstrated to reduce markers of stress or anxiety in adult dogs, though the quantity of evidence was low.	View
Melissa officinalis (Lemon balm)	D	There is insufficient evidence to determine evidence-based conclusions regarding the efficacy of melissa officinalis	View
Valerian Root	D	There is insufficient evidence to demonstrate valerian root as an effective calming or anxiety relieving supplement, though early evidence for use as a diffuser did not support efficacy.	View